C9H14O6 218.21

1,2,3-Propanetriol triacetate.
Triacetin.
Glyceryl triacetate [102-76-1].

Packaging and storage— Preserve in tight containers.

USP Reference standards 11— USP Triacetin RS.

Identification—

Specific gravity 841: not less than 1.152 and not more than 1.158.

Refractive index 831: not less than 1.429 and not more than 1.430.

Acidity— Dilute 25 g of Triacetin, accurately weighed, with 50 mL of neutralized alcohol, add 5 drops of phenolphthalein TS, and titrate with 0.020 N sodium hydroxide: not more than 1.0 mL of 0.020 N sodium hydroxide is required for neutralization.

Water, Method I 921: not more than 0.2% is found.

Residual solvents 467: meets the requirements.

Assay— Transfer about 1 g of Triacetin, accurately weighed, to a 250-mL boiling flask, add 50.0 mL of 0.5 N alcoholic potassium hydroxide VS, connect the flask to a water-jacketed condenser, and reflux on a steam bath for 45 minutes, swirling frequently. Cool, add 5 drops of phenolphthalein TS, and titrate the excess alkali with 0.5 N hydrochloric acid VS. Perform a blank determination (see Residual Titrations under Titrimetry 541). Each mL of 0.5 N alcoholic potassium hydroxide is equivalent to 36.37 mg of C9H14O6.

Expert Committee : (MDAA05) Monograph Development-Antivirals and Antimicrobials

USP29–NF24 Page 2182

Phone Number : 1-301-816-8394