Search USP29  
Sodium Tartrate
Click to View Image
C4H4Na2O6·2H2O 230.08

Disodium L-tartrate.
Disodium (+)-2,3-dihydroxybutanedioic acid [868-18-8].
» Sodium Tartrate contains not less than 99.0 percent and not more than 100.5 percent of C4H4Na2O6·2H2O, calculated on the dried basis.
Add the following:
Packaging and storage— Preserve in a tight container. No storage requirements specified.NF24
A: Responds to the tests for Sodium 191.
B: Responds to the tests for Tartrate 191.
pH 791: between 7 and 9 (1 in 10 solution).
Loss on drying 731 Dry it at 150 for 3 hours: it loses between 14.0% and 17.0% of its weight.
Limit of oxalate— Dissolve 1.0 g of Sodium Tartrate in 10 mL of water, then add 5 drops of diluted acetic acid and 2 mL of calcium chloride TS: no turbidity develops within 1 hour. Not more than 0.1% is found.
Residual solvents 467: meets the requirements.
(Official January 1, 2007)
Assay— Transfer about 250 mg of Sodium Tartrate, accurately weighed and previously dried at 150 for 3 hours, to a 250-mL beaker, and dissolve by stirring and heating to near the boiling point in 150 mL of acetic acid. Cool the solution to room temperature. Titrate with 0.1 N perchloric acid VS (in glacial acetic acid), determining the endpoint potentiometrically. Perform a blank determination, and make any necessary adjustments (see Titrimetry 541). Each mL of 0.1 N perchloric acid is equivalent to 9.703 mg of C4H4Na2O6.
Auxiliary Information— Staff Liaison : Catherine Sheehan, B.Sc., Scientist
Expert Committee : (EM105) Excipient Monographs 1
USP29–NF24 Page 3429
Pharmacopeial Forum : Volume No. 31(1) Page 95
Phone Number : 1-301-816-8262