C
8H
11NO
3·C
4H
6O
6·H
2O
337.28
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (
R)-,[
R-(
R*,
R*)]-2,3-dihydroxybutanedioate (1:1) (salt), monohydrate.
(
)-
-(Aminomethyl)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt), monohydrate
[
69815-49-2].
Anhydrous
319.27
[
51-40-1].
Packaging and storage—
Preserve in tight, light-resistant containers. Store at 25
, excursions permitted between 15
and 30
.
Identification—
B:
To a solution of 10 mg in 2 mL of water add 1 drop of
ferric chloride TS: an intensely green color develops.
C:
To 10 mL of a solution (1 in 10,000) add 1.0 mL of 0.10 N iodine. Allow to stand for 5 minutes, and add 2.0 mL of 0.10 N sodium thiosulfate: the solution is colorless or has at most a slight pink or slight violet color (epinephrine and isoproterenol at the same pH, about 3.5, give a strong red-brown or violet color).
Specific rotation 
781S
:
between
10
and
12
.
Test solution:
50 mg per mL, in water.
Assay—
Dissolve about 500 mg of Norepinephrine Bitartrate, accurately weighed, in 20 mL of glacial acetic acid, warming slightly if necessary to effect solution. Add 2 drops of
crystal violet TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 31.93 mg of C
8H
11NO
3·C
4H
6O
6.
;)