Packaging and storage—
Preserve in tight containers, and store at controlled room temperature.
Labeling—
Label Boluses to indicate that they are for veterinary use only.
Identification—
To a portion of powdered Boluses add 0.1 N hydrochloric acid to obtain a test solution containing about 4 mg of amoxicillin per mL. Proceed as directed for the
Identification test under
Amoxicillin Tablets, beginning with “Prepare a Standard solution.” The specified result is obtained.
Assay—
Diluent, Mobile phase, Standard preparation, and Chromatographic system—
Prepare as directed in the
Assay under
Amoxicillin.
Assay preparation—
Weigh and finely powder not fewer than 5 Boluses. Transfer an accurately weighed portion of the powder, equivalent to about 250 mg of amoxicillin, to a 250-mL volumetric flask, add Diluent to volume, and mix. Sonicate if necessary to ensure complete dissolution of the amoxicillin. Pass a portion of this solution through a filter of 1-µm or finer porosity, and use the filtrate as the Assay preparation. [NOTE—Use this solution within 6 hours.]
Procedure—
Proceed as directed for
Procedure in the
Assay under
Amoxicillin. Calculate the quantity, in mg, of amoxicillin (C
16H
19N
3O
5S) in the portion of Boluses taken by the formula:
0.25CP(rU / rS),
in which the terms are as defined therein.
701
:
30 minutes, simulated gastric fluid being used instead of water.