C
11H
9I
3N
2O
4 (anhydrous)
613.91
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-.
3,5-Diacetamido-2,4,6-triiodobenzoic acid
[
117-96-4].
Dihydrate
649.95
[
50978-11-5].
Packaging and storage
Preserve in well-closed containers. Store at room temperature.
Labeling
Label it to indicate whether it is anhydrous or hydrous.
Identification
A:
It responds to the
Thin-Layer Chromatographic Identification Test 201, the test solution and the Standard solution being prepared at a concentration of 1 mg per mL in a 0.8 in 1000 solution of sodium hydroxide in methanol, the solvent mixture being a mixture of chloroform, methanol, and ammonium hydroxide (20:10:2), and short-wavelength UV light being used to locate the spots.
B:
Heat about 500 mg in a suitable crucible: violet vapors are evolved.
Water, Method I 921:
not more than 1.0% (anhydrous form), and between 4.5% and 7.0% (hydrous form).
Iodine and iodide
Test preparation
Suspend 10.0 g in 10 mL of water, and add in small portions, with stirring, 1.5 mL of sodium hydroxide solution (2 in 5). When solution is complete, adjust to a pH between 7.0 and 7.5 with a dilute solution (1 in 125) of sodium hydroxide or hydrochloric acid, and dilute with water to 20 mL.
Procedure
Dilute 4.0 mL of
Test preparation with 20 mL of water in a 50-mL centrifuge tube provided with a stopper, and proceed as directed for
Procedure under
Diatrizoate Meglumine.
Heavy metals 231
To a 50-mL color-comparison tube transfer 2.0 mL of solution prepared as directed for
Test preparation in the test for
Iodine and iodide, add 5 mL of 1 N sodium hydroxide, dilute with water to 40 mL, and mix. Using this as the
Test preparation, proceed as directed in the test for
Heavy metals under
Diatrizoate Meglumine: the limit is 0.002%.
Free aromatic amine
Transfer 1.0 g to a 50-mL volumetric flask, and add 12.5 mL of water and 2.5 mL of 1 N sodium hydroxide. Proceed as directed in the test for
Free aromatic amine under
Diatrizoate Meglumine, beginning with To a second 50-mL volumetric flask transfer 4 mL of water. The absorbance of the solution from the Diatrizoic Acid is not greater than that of the Standard solution (0.05%).
Assay
Transfer about 300 mg of Diatrizoic Acid, accurately weighed, to a glass-stoppered, 125-mL conical flask, and proceed as directed in the
Assay under
Diatrizoate Meglumine, beginning with add 30 mL of 1.25 N sodium hydroxide. Each mL of 0.05 N silver nitrate is equivalent to 10.23 mg of C
11H
9I
3N
2O
4.