Packaging and storage
Preserve in well-closed containers.
Identification
A solution of Tablets responds to the tests for
Sodium 191 and for
Bicarbonate 191.
Disintegration 701:
30 minutes, simulated gastric fluid TS being substituted for water in the test.
Assay
Weigh and finely powder not less than 20 Tablets. Weigh accurately a portion of the powder, equivalent to about 2 g of sodium bicarbonate, dissolve in 100 mL of water, add methyl red TS, and titrate with 1 N hydrochloric acid VS. Add the acid slowly, with constant stirring, until the solution becomes faintly pink. Heat the solution to boiling, cool, and continue the titration until the pink color no longer fades after boiling. Each mL of 1 N hydrochloric acid is equivalent to 84.01 mg of NaHCO3.