USP Monographs: Aspirin Effervescent Tablets for Oral Solution

Aspirin Effervescent Tablets for Oral Solution

» Aspirin Effervescent Tablets for Oral Solution contain Aspirin and an effervescent mixture of a suitable organic acid and an alkali metal bicarbonate and/or carbonate. Tablets contain not less than 90.0 percent and not more than 110.0 percent of the labeled amount of aspirin (C9H8O4).

Packaging and storage— Preserve in tight containers.

USP Reference standards

— USP Aspirin RS. USP Salicylic Acid RS.

Identification—

A: Dissolve 1 Tablet in about 50 mL of 1 N hydrochloric acid, boil for about 5 minutes, and allow to cool. To 2 mL of the resulting solution add 2 or 3 drops of ferric chloride TS: a violet-red color is produced.

B: Add about one-half a Tablet to 50 mL of water in a flask, and immediately stopper with a stopper fitted with tubing so that the evolved gas passes through calcium hydroxide TS: a white precipitate forms.

Solution time— Two Tablets dissolve completely in 180 mL of water at 17.5 ± 2.5

within 5 minutes.