U.S. PHARMACOPEIA

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Monoethanolamine
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C2H7NO 61.08

Ethanol, 2-amino-.
2-Aminoethanol [141-43-5].
» Monoethanolamine contains not less than 98.0 percent and not more than 100.5 percent, by weight, of C2H7NO.
Packaging and storage— Preserve in tight, light-resistant containers.
Specific gravity 841: between 1.013 and 1.016.
Distilling range, Method II 721 Not less than 95% of it distills between 167 and 173, a correction factor of 0.052 per mm being applied as necessary.
Residue on ignition 281: not more than 0.1%.
Residual solvents 467: meets the requirements.
(Official January 1, 2007)
Assay— Accurately weigh a glass-stoppered weighing bottle containing 25 mL of water. Add 1 g of Monoethanolamine, and weigh. Transfer to a suitable flask, add a mixed indicator of 5 parts bromocresol green TS and 6 parts methyl red TS for a total of approximately 11 parts of solution, mix, and titrate with 0.5 N hydrochloric acid VS. Each mL of 0.5 N hydrochloric acid is equivalent to 30.54 mg of C2H7NO.
Auxiliary Information— Staff Liaison : Catherine Sheehan, B.Sc., Scientist
Expert Committee : (EM105) Excipient Monographs 1
USP29–NF24 Page 3376
Pharmacopeial Forum : Volume No. 31(5) Page 1425
Phone Number : 1-301-816-8262