Labeling—
The label states the Latin binomial and, following the official name, the part of the plant from which the article was derived. The label also indicates the content of glycyrrhizic acid, the extracting solvent or solvent mixture used for preparation, and the ratio of the starting material to final product. The label bears a statement indicating that “Excessive amounts or long-term use of Licorice may cause high blood pressure or low potassium, which have been associated with irregular heartbeat and/or muscle weakness. Licorice may worsen the effects of congestive heart failure, cirrhosis, or kidney failure. Diuretic use may increase the risk. If you are pregnant or nursing a baby, seek the advice of a health professional before using this product.” It meets the requirements for
Labeling under
Botanical Extracts 
565
.
Content of glycyrrhizic acid—
Solvent, Mobile phase, Standard solution, and Chromatographic system—
Proceed as directed for Content of glycyrrhizic acid under Licorice.
Test solution—
Transfer about 150 mg of Powdered Extract, accurately weighed, to a suitable flask, add 25 mL of
Solvent, heat at 50
for 30 minutes, cool, centrifuge, and decant the supernatant into a 100-mL volumetric flask. Mix the residue with 20 mL of
Solvent, repeat the above procedure, and dilute with
Solvent to volume.
Procedure—
Proceed as directed for
Content of glycyrrhizic acid under
Licorice, except to calculate the percentage of glycyrrhizic acid (C
42H
62O
16) in the portion of Powdered Extract taken by the formula:
10,000(C/W)(rU / rS),
in which
W is the weight, in mg, of the Powdered Extract taken to prepare the
Test solution; and the other terms are as defined therein.
