Packaging and storage— Preserve in tight containers, remote from heat.

Labeling— Label it to indicate that it is flammable.

Specific gravity 841: between 0.872 and 0.883 at 20.

Acidity— Transfer 50 mL to a suitable flask, and add about 75 mL of carbon dioxide-free water. Titrate potentiometrically to a pH of 8.5: not more than 1.0 mL of 0.020 N sodium hydroxide is required for neutralization.

Limit of nonvolatile residue— Evaporate 50 mL to dryness in a tared porcelain dish on a steam bath, and dry at 105 for 1 hour: the weight of the residue does not exceed 5 mg (0.01%).

Residual solvents 467: meets the requirements.

Assay— Transfer 50.0 mL of Isopropyl Rubbing Alcohol to a 250-mL distilling flask, and add 100 mL of water. Arrange the flask for distillation, distil, and collect 95 mL of distillate in a 100-mL volumetric flask. Dilute to volume with water, mix, and determine the specific gravity of the distillate at 25 (see Specific Gravity 841). The specific gravity is between 0.955 and 0.950, corresponding to between 68.0% and 72.0% of isopropyl alcohol in the specimen taken.

Expert Committee : (MDAA05) Monograph Development-Antivirals and Antimicrobials

USP29–NF24 Page 1192

Phone Number : 1-301-816-8394