C9H10O3 166.17

Benzaldehyde, 3-ethoxy-4-hydroxy-.
3-Ethoxy-4-hydroxybenzaldehyde [121-32-4].

Packaging and storage— Preserve in tight, light-resistant containers.

USP Reference standards 11— USP Ethyl Vanillin RS.

Identification—

Melting range 741: between 76 and 78.

Loss on drying 731— Dry it over phosphorus pentoxide for 4 hours: it loses not more than 1.0% of its weight.

Residue on ignition 281: not more than 0.1%.

Organic volatile impurities, Method IV 467: meets the requirements.

Residual solvents 467: meets the requirements.

Assay— Dissolve about 300 mg of Ethyl Vanillin, previously dried and accurately weighed, in 50 mL of dimethylformamide contained in a 125-mL conical flask. Add thymol blue TS, and titrate with 0.1 N sodium methoxide VS, using a magnetic stirrer and taking precautions against the absorption of atmospheric carbon dioxide. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N sodium methoxide is equivalent to 16.62 mg of C9H10O3.

Expert Committee : (EM105) Excipient Monographs 1

USP29–NF24 Page 3331

Phone Number : 1-301-816-8262