CH6N2O3 94.07

Urea, compd. with hydrogen peroxide (1:1).
Urea compound with hydrogen peroxide (1:1) [124-43-6].

Packaging and storage— Preserve in tight, light-resistant containers, and avoid exposure to excessive heat.

Identification—

Organic volatile impurities, Method I 467: meets the requirements.

Residual solvents 467: meets the requirements.

Assay— Transfer about 100 mg of Carbamide Peroxide, accurately weighed, to a 500-mL iodine flask with the aid of 25 mL of water, add 5 mL of glacial acetic acid, and mix. Add 2 g of potassium iodide and 1 drop of ammonium molybdate TS, insert the stopper, and allow to stand in the dark for 10 minutes. Titrate the liberated iodine with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is approached. Each mL of 0.1 N sodium thiosulfate is equivalent to 4.704 mg of CH6N2O3.

Expert Committee : (MDPS05) Monograph Development-Pulmonary and Steroids

USP29–NF24 Page 374

Phone Number : 1-301-816-8143